Nature

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

…, EM McLoughlin, Y Brudno, S Mahapatra, P Kapranov…

文献索引：Pastor, William A.; Pape, Utz J.; Huang, Yun; Henderson, Hope R.; Lister, Ryan; Ko, Myunggon; McLoughlin, Erin M.; Brudno, Yevgeny; Mahapatra, Sahasransu; Kapranov, Philipp; Tahiliani, Mamta; Daley, George Q.; Liu, X. Shirley; Ecker, Joseph R.; Milos, Patrice M.; Agarwal, Suneet; Rao, Anjana Nature, 2011 , vol. 473, # 7347 p. 394 - 397

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被引用次数: 542

摘要

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mammals 1, 2, 3, 4, 5. 5hmC is generated by the TET family of Fe (II) and 2- oxoglutarate-dependent enzymes through oxidation of 5-methylcytosine (5mC) 1, 2, 4, 5, 6, 7. 5hmC and TET proteins have been implicated in stem cell biology and cancer 1, 4, 5, 8, 9, but information on the genome-wide distribution of 5hmC is limited. Here we describe two ...