Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type

EE Galantay, R Simpson, G Corriveau…

文献索引：Galantay,E.E. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1316 - 1327

全文：HTML全文

被引用次数: 9

摘要

The preparation of a series of novel tricyclic ketones-heterocyclic analogs of dibenzosuberone-is described. These compounds served as intermediates toward analogs of the amitriptyline type in which an oxazole, thiazole, or imidazole ring was substituted for one of the benzene moieties. The oxazole and thiazole analogs of amitriptyline were highly potent CNS depressant drugs. This CNS depressant spectrum could be shifted toward an ...