N-(Indol-3-ylglyoxylyl) methionine derivatives: preparation and gastric anti-secretory activity

A Da Settimo, G Primofiore, AM Marini…

文献索引：Settimo, Antonio da; Primofiore, Giampaolo; Marini, Anna Maria; Ferrarini, Pier Luigi; Franzone, Jose Sebastian; et al. European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 21 - 24

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被引用次数: 13

摘要

Abstract The authors describe the synthesis of several N-(indol-3-ylglyoxylyl) methionine derivatives. The target compounds were prepared starting from substituted indoleglyoxylyl chlorides and methionine ethyl ester. Some of them were tested for their gastric anti- secretory activity. Among these compounds, the N-(5-chloroindol-3-ylglyoxylyl) methionine Ve was the most active, being quite comparable to cimetidine.