Synthesis and Platelet Aggregation Inhibitory Activity of Diphenylazole Derivatives. I. Thiazole and Imidazole Derivatives

…, K YOSHINO, K YOKOTA, G TSUKAMOTO

文献索引：Seko; Yoshino; Yokota; Tsukamoto Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 651 - 657

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被引用次数: 3

摘要

Diphenylimidazole and diphenylthiazole derivatives were synthesized and tested as inhibitors of platelet aggregation in in vitro experiments with the rabbit. Diphenylthiazole derivatives (10) were more potent than diphenylimidazole derivatives (4) in inhibiting arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. Two diphenylimidazole and eight diphenylthiazole derivatives were evaluated for ex vivo ...