A new class of anticonvulsants possessing 6Hz activity: 3, 4-Dialkyloxy thiophene bishydrazones

R Kulandasamy, AV Adhikari, JP Stables

文献索引：Kulandasamy, Ravi; Adhikari, Airody Vasudeva; Stables, James P. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4376 - 4384

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被引用次数: 44

摘要

Thirty nine new 3, 4-di (substituted) oxy-N2, N5-bis (substituted) thiophene-2, 5- dicarbohydrazides were synthesized starting from ethyl thiodiglycolate through multi-step reactions. In the synthetic sequence, 3, 4-dihydroxythiophene-2, 5-diester (1) was obtained by condensing the ethyl thiodiglycolate with diethyl oxalate. It was derivatized using different alkyl halides to give disubstituted thiophene esters (2–5), which were then converted to ...