European Journal of Organic Chemistry

Asymmetric Synthesis of (S)??(−)??Acromelobic Acid

N Wild, U Groth

文献索引：Wild, Nicole; Groth, Ulrich European Journal of Organic Chemistry, 2003 , # 22 p. 4445 - 4449

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被引用次数: 5

摘要

Abstract (S)-(−)-Acromelobic acid (1) was synthesized in nine steps in enantiomerically pure form from citrazinic acid (4) in an overall yield of 21%. The key steps of this synthesis are the introduction of the amino function by the bis (lactim) ether method and the introduction of the acid function by Stille coupling.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)