Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo [1, 2-a] pyridines and analogs

JJ Kaminski, JM Hilbert, BN Pramanik…

文献索引：Kaminski, James J.; Hilbert, James M.; Pramanik, B. N.; Solomon, Daniel M.; Conn, David J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2031 - 2046

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被引用次数: 58

摘要

The search for a successor to 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy) imidazo [l, 2-a] pyridine, Sch 28080 (271, a compound that exhibits gastric antisecretory and cytoprotective properties and has undergone clinical evaluation as an antiulcer agent, has culminated in the identification of four related compounds that exhibit pharmacologic profiles similar to that of 27. In three of these potential successors an amino group functions as a surrogate for ...