Structure− Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H-chromene-3-carboxylate (sHA 14-1) and Its …

SG Das, JM Doshi, D Tian, SN Addo…

文献索引：Doshi, Jignesh M.; Tian, Defeng; Xing, Chengguo Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7731 - 7739

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被引用次数: 44

摘要

Rapid development of multiple drug resistance against current therapies is a major barrier in the treatment of cancer. Therefore, anticancer agents that can overcome acquired drug resistance in cancer cells are of great importance. Previously, we have demonstrated that ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H-chromene-3-carboxylate (5a, sHA 14- 1), a stable analogue of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4 H- ...