Analytical chemistry

Multilabeling biomolecules at a single site. 1. Synthesis and characterization of a dendritic label for electrochemiluminescence assays

…, J Roovers, GP Robertson, CP Grover

文献索引：Zhou, Ming; Roovers, Jacques; Robertson, Gilles P.; Grover, Chander P. Analytical Chemistry, 2003 , vol. 75, # 23 p. 6708 - 6717

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被引用次数: 91

摘要

Ultrasensitive bioanalytical assays are of great value for early detection of human diseases and pathogens. The sensitivities of immunoassays and DNA probing can be enhanced by multilabeling the biorecognition partner used for affinity-based assays. However, the bioreactivity of biomolecules is affected by a high degree of multilabeling at multiple functional sites. It is proposed that dendritic scaffoldings be used to link multiple signal- ...