Abstract A series of C??3, 4, 5??substituted 2, 6??dimethyl??1, 4??dihydropyridines (1, 4??DHPs) with pharmacological properties were prepared by a variation from the classical Hantzsch synthesis. The procedure involves treatment of the respective aldehyde with either ethyl??3?? aminocrotonate or 3??aminocrotonitrile in anhydrous acetic acid at temperatures not exceeding 60° C, thus minimizing by??product formation. The structures of title compounds ...
