Scaling up of dihydropyridine ester synthesis by using aqueous hydrotrope solutions in a continuous microwave reactor

BM Khadilkar, VR Madyar

文献索引：Khadilkar, Bhushan M.; Madyar, Virendra R. Organic Process Research and Development, 2001 , vol. 5, # 4 p. 452 - 455

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被引用次数: 59

摘要

We report here the scaling up of clinically important dihydropyridine by using a continuous microwave reactor (CMR). We also report the use of aqueous hydrotrope solution as a cheap, safe and “green” alternative to organic solvent to carry out homogeneous reactions under microwave heating. We have studied different aqueous hydrotrope solutions for the reaction in batch as well as continuous-flow process.