Chemistry–A European Journal

Total synthesis of salicylihalamides A and B

C Herb, A Bayer, ME Maier

文献索引：Herb, Christian; Bayer, Alexander; Maier, Martin E. Chemistry - A European Journal, 2004 , vol. 10, # 22 p. 5649 - 5660

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被引用次数: 38

摘要

Abstract The paper illustrates two efficient routes to macrolactone 19 containing a 3-(para- methoxybenzyloxy) propyl side chain at C-15. The chiral center at C-15 was introduced by a Noyori reduction of keto ester 5. The intermediate common to both routes, aldehyde 8, was prepared from keto ester 5. The subsequent chain extension utilized Evans aldol reactions. The first route leads to the alkene 14, which was used, after hydroboration, for a Suzuki ...