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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

JH Byun, HY Kim, YS Kim, I Mook-Jung, DJ Kim…

文献索引：Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5591 - 5593

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被引用次数: 46

摘要

The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a–w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50= 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50= 0.80 μM) and IMSB ...

4-溴-2-羟基苯甲醛结构式

4-溴-2-羟基苯甲醛

溴乙酸乙酯结构式

溴乙酸乙酯

~%

6-溴苯并呋喃-2-羧酸乙酯结构式

6-溴苯并呋喃-2-羧酸乙酯

6-溴苯并呋喃-2-羧酸乙酯结构式

6-溴苯并呋喃-2-羧酸乙酯

~%

(6-Bromo-1-benzofuran-2-yl)methanol结构式

(6-Bromo-1-benz...

二碳酸二叔丁酯结构式

二碳酸二叔丁酯

对氨基苯甲酸结构式

对氨基苯甲酸

~10%

4-(Boc-氨基)苯甲醇结构式

4-(Boc-氨基)苯甲醇

2-羟基-4-碘苯甲醛结构式

2-羟基-4-碘苯甲醛

溴乙酸乙酯结构式

溴乙酸乙酯

~%

Ethyl 6-iodo-1-benzofuran-2-carboxylate结构式

Ethyl 6-iodo-1-...

Ethyl 6-methyl-1-benzofuran-2-carboxylate结构式

Ethyl 6-methyl-...

~%

(6-Methyl-1-benzofuran-2-yl)methanol结构式

(6-Methyl-1-ben...

2-Benzofurancarboxylic acid, 5-Methyl-, ethyl ester结构式

2-Benzofurancar...

~%

(5-methylbenzofuran-2-yl)methanol结构式

(5-methylbenzof...

2-羟基-4-甲基苯甲醛结构式

2-羟基-4-甲基苯甲醛

溴乙酸乙酯结构式

溴乙酸乙酯

~%

Ethyl 6-methyl-1-benzofuran-2-carboxylate结构式

Ethyl 6-methyl-...

5-碘水杨醛结构式

溴乙酸乙酯结构式

溴乙酸乙酯

~%

ethyl 5-iodo-1-benzofuran-2-carboxylate结构式

ethyl 5-iodo-1-...

Use of Conformationally Restricted Benzamidines as Arginine ...

[Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857]

Use of Conformationally Restricted Benzamidines as Arginine ...

[Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857]

Use of Conformationally Restricted Benzamidines as Arginine ...

[Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857]

Use of Conformationally Restricted Benzamidines as Arginine ...

[Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857]

Use of Conformationally Restricted Benzamidines as Arginine ...

[Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857]