Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4, 6- …

…, G Schneider, M Schubert-Zsilavecz…

文献索引：Zettl, Heiko; Steri, Ramona; Laemmerhofer, Michael; Schubert-Zsilavecz, Manfred Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4421 - 4426

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被引用次数: 24

摘要

Various inflammatory diseases are associated with the excessive formation of leukotrienes (LTs) and prostaglandins (PGs). Herein, we present a novel class of dual inhibitors of 5- lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), key