A sphingosine 1-phosphate receptor 2 selective allosteric agonist

…, M Guerrero, A Saldana, C Eberhart, P Hodder…

文献索引：Satsu, Hideo; Schaeffer, Marie-Therese; Guerrero, Miguel; Saldana, Adrian; Eberhart, Christina; Hodder, Peter; Cayanan, Charmagne; Schuerer, Stephan; Bhhatarai, Barun; Roberts, Ed; Rosen, Hugh; Brown, Steven J. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5373 - 5382

全文：HTML全文

被引用次数: 15

摘要

Abstract Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple biological processes in which the S1PR2 receptor has been implicated. Amongst these are NF-κB-mediated tumor cell survival and fibroblast chemotaxis to fibronectin. Here we report our efforts to identify selective chemical probes for S1PR2 and their characterization. We employed high ...