A novel approach to Finafloxacin hydrochloride (BAY35-3377)

…, Z Zhang, H Lei, H Cheng, Y Hu, W Yang, Y Liang…

文献索引：Hong, Jian; Zhang, Zonghua; Lei, Huoxing; Cheng, Haiying; Hu, Yufang; Yang, Wanliang; Liang, Yinglin; Das, Debasis; Chen, Shu-Hui; Li, Ge Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2525 - 2528

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被引用次数: 11

摘要

Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4- oxo-1, 4-dihydroquinoline-3-carboxylate 19 was prepared by a new route. The chiral (S, S′)-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis.