From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 …

Y Cheng, TC Judd, MD Bartberger…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 16 p. 5836 - 5857

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被引用次数: 78

摘要

... Journal of Medicinal Chemistry. ... underlying disease pathophysiology. A therapeutic treatment that directly modifies the progression of the disease remains one of the largest unmet medical needs. The pathological ...