Journal of medicinal chemistry

Irreversible enzyme inhibitors. 202. Candidate active-site-directed irreversible inhibitors of 5-fluoro-2'-deoxyuridine phosphorylase from Walker 256 rat tumor derived …

JL Kelley, BR Baker

文献索引：Kelley, James L.; Baker, B. R. Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 600 - 603

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被引用次数: 16

摘要

Six candidate irreversible inhibitors of uridine-deoxyuridine phosphorylase (EC 2.4. 2.3) from Walker 256 rat tumor were synthesized. These compounds connect a terminal sulfonyl fluoride group to the 1-benzyl moiety of 1-benzyl-5-(3-ethoxybenzyl) uracil (9). Although none of the compounds were irreversible inhibitors, the four 3-[(fluorosulfonyl) benido] analogues (14-17) of 9 were good reversible inhibitors of the enzyme which were ...