Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells
…, S Guruswamy, D Brown, GJ Gardner…
文献索引：Liu, Shengquan; Brown, Chad W.; Berlin, K. Darrell; Dhar, Aridam; Guruswamy, Suresh; Brown, David; Gardner, Ginger J.; Birrer, Michael J.; Benbrook, Doris M. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 999 - 1007
Regulation of growth, differentiation, and apoptosis by synthetic retinoids can occur through mechanisms that are dependent and independent of their ability to bind and activate nuclear retinoic acid receptors. The objective of this study was to determine if increasing flexibility of the heteroarotinoid structure would affect the specificity of the synthetic retinoids for the receptors and for their regulation of cancerous and nonmalignant cells. Methods were ...
