Structural Prerequisites for Receptor Binding of Helicokinin I, a Diuretic Insect Neuropeptide from Helicoverpa zea

…, D Nennstiel, O Zerbe, J Scherkenbeck

文献索引：Van, Chien Tran; Zdobinsky, Tino; Seebohm, Guiscard; Nennstiel, Dirk; Zerbe, Oliver; Scherkenbeck, Juergen European Journal of Organic Chemistry, 2014 , vol. 2014, # 13 p. 2714 - 2725

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摘要

Abstract In insects essential physiological processes such as muscle activity or water balance are controlled by neuropeptides. However, owing to their metabolic instability and adverse physicochemical properties peptides are unsuited as crop protection agents. Helicokinin I, a diuretic neuropeptide of cotton pest Helicoverpa zea represents a most promising target for the design of neuropeptide mimetics. Several helicokinin analogues ...