Synthesis and bioactivity of a new class of rigid glutamate analogs. Modulators of the N-methyl-D-aspartate receptor
AP Kozikowski, W Tuckmantel…
文献索引：Kozikowski, Alan P.; Tueckmantel, Werner; Reynolds, Ian J.; Wroblewski, Jarda T. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1561 - 1571
'C02H in both the induction of LTP (long term potentiation, a current model of mem01-y)~ and in the neuronal degeneration resulting from the ischemic conditions accompanying a stroke or heart attack. 6 The latter state is presumably reached when excessive amounts of the excitatory amino acids, glutamate or aspartate, are released, leading to an over- stimulation of NMDA receptors with consequent alterations in the calcium fluxes. ...
