Design, synthesis, and structure-activity Relationships of a new series of. alpha.-adrenergic agonists: spiro [(1, 3-diazacycylpent-1-ent)-5, 2'-(1', 2', 3', 4'- …
The contractions induced by a partial al-adrenoceptor agonist in cutaneous veins, such as the saphenous vein, show a particular sensitivity to changes in local temperature: the contractility to a partial al-adrenoceptor agonist increases when the temperature is raised, a response that contrasts to that noted with full al- and az-adrenoceptor agonists. This observation may be of importance for the treatment of the symptoms of venous insuffiency, favored during warm ...
