Mammalian antifertility agents. IV. Basic 3, 4-dihydronaphthalenes and 1, 2, 3, 4-tetrahydro-1-naphthols

D Lednicer, SC Lyster, GW Duncan

文献索引：Lednicer,D. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 78 - 84

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被引用次数: 95

摘要

CH 0 m'H-'28 opened with succininiide to afford 21. Basic hydrolysis of this last product led cleanly to 28. To assess the properties of the phenolic amine, the starting tetralone 17 was demethylated by means of aluminum chloride to give 22. Reaction of the phenolic ketone (as its tetrahydropyranyl ether) with the appropriate Grignard reagent followed by mild hydrolysis led to the aminophenol 27 (Tables I11 and IV).