Convenient two-step conversion of lactones into cyclic ethers

…, X Verdaguer, SL Buchwald

文献索引：Hansen, Marcus C.; Verdaguer, Xavier; Buchwald, Stephen L. Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2360 - 2361

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被引用次数: 25

摘要

We recently developed a new method for the reduction of lactones that offers easy access to five-and sixmembered ring lactols using a titanocene diphenoxide (1a)/tetrabutylammonium fluoride/alumina mixture or titanocene difluoride (1b) as the catalyst; 1 polymethylhydrosiloxane (PMHS) was used as the stoichiometric reductant (Scheme 1). A variety of lactones were reduced to the corresponding lactols in good to excellent yields.