Bioorganic & medicinal chemistry

Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and β-secretase inhibitory activity

S Marumoto, M Miyazawa

文献索引：Marumoto, Shinsuke; Miyazawa, Mitsuo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 455 - 459

全文：HTML全文

被引用次数: 18

摘要

Biotransformation studies conducted on the furanocoumarins isoimperatorin (1) and imperatorin (3) have revealed that 1 was metabolized by Glomerella cingulata to give the corresponding reduced acid, 6, 7-furano-5-prenyloxy hydrocoumaric acid (2), and 3 was transformed by G. cingulata to give the dealkylated metabolite, xanthotoxol (4) in high yields (83% and 81%), respectively. The structures of the new compound 2 have been ...