The Journal of Organic Chemistry

Synthesis of biologically active metabolites of 7-methylbenz [a] anthracene

HM Lee, RG Harvey

文献索引：Lee,H.M.; Harvey,H.R. Journal of Organic Chemistry, 1979 , vol. 44, p. 4948 - 4953

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被引用次数: 21

摘要

Syntheses are described of the trans 3, 4-dihydro diol (la) and the corresponding anti diol epoxide (2) of 7-methylbenz [alanthracene, implicated as proximate and ultimate carcinogenic metabolites, respectively, of this potent precarcinogen. Additional syntheses are reported of the related trans 1, Zdihydro diol (3a), the corresponding anti and syn diol epoxides, and 2-and 3-hydroxy-7-methylbenz [a] anthracene, additional potential ...