The Journal of Organic Chemistry

Efficient synthesis of non-K-region trans-dihydrodiols of polycyclic aromatic hydrocarbons from o-quinones and catechols

KL Platt, F Oesch

文献索引：Platt, Karl L.; Oesch, Franz Journal of Organic Chemistry, 1983 , vol. 48, # 2 p. 265 - 268

全文：HTML全文

被引用次数: 106

摘要

Non-K-region'dihydro diols of polycyclic aromatic hydrocarbons (PAH), generated by the epoxide hydrolase mediated hydration of metabolically formed arene oxides, play an important role in the metabolism of PAH. 2-7 They are precursors of dihydro diol epoxides, some of which are considered to be ultimate carcinogenic metabolites of PAH. &'O