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High-affinity multivalent wheat germ agglutinin ligands by one-pot click reaction

HSG Beckmann, HM Möller…

文献索引:Beckmann, Henning S.G.; Moeller, Heiko M.; Wittmann, Valentin Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 819 - 826

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被引用次数: 20

摘要

Abstract A series of six mono-, di-, and trivalent N, N'-diacetylchitobiose derivatives was conveniently prepared by employing a one-pot procedure for Cu (II)-catalyzed diazo transfer and Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) starting from commercially available amines. These glycoclusters were probed for their binding potencies to the plant lectin wheat germ agglutinin (WGA) from Triticum vulgaris by an enzyme-linked lectin ...