Tetrahedron letters

Sequential mono-N-arylation of piperazine nitrogens. Part 1: A simplified method and its application to the preparation of a key N, N′-biaryl piperazine antifungal …

M Hepperle, J Eckert, D Gala

文献索引：Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659

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被引用次数: 34

摘要

A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N, N′-biarylated piperazine antifungal intermediate N-(4- hydroxyphenyl)-N′-(4-aminophenyl) piperazine, 6, is described.