A Novel Palladium??Catalyzed Domino Tsuji− Trost− Heck Process for the Synthesis of Tetrahydroanthracenes

LF Tietze, G Nordmann

文献索引：Tietze, Lutz F.; Nordmann, Gero European Journal of Organic Chemistry, 2001 , # 17 p. 3247 - 3253

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被引用次数: 16

摘要

Abstract A novel type of palladium-catalyzed domino reaction is described combining Tsuji− Trost and Heck reactions. This method allows efficient access to tetrahydroanthracene derivatives 1 in up to 89% isolated yield in a one-pot process starting from the diketone 3. The tetrahydroanthracene structural motif is found in many natural products, such as in the antibiotic tetracycline.