Hydrolysis of the amide bond is a major target of research in catalytic antibodies. This approach could be of use in the design of catalysts for sequence specific peptide hydrolysis; however, amide hydrolysing antibodies are still rare in spite of many efforts. So far, the only successful approach to amidase-like antibodies has been based on the use of phosphinate or phosphonate esters' and amides2 as haptenic transition state analogues (TSA). In contrast, ...
