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A novel synthetic approach towards pyrazole-4-carboxamides using N-(3-(dimethylamino)-2-formylacryloyl) formamide

MN Jachak, MG Ghagare, DR Birari, RV Rote…

文献索引:Jachak, Madhukar N.; Ghagare, Maruti G.; Birari, Dilip R.; Rote, Ramhari V.; Kazi, Muddassar A.; Jachak, Sanjay M.; Toche, Raghunath B. Monatshefte fur Chemie, 2010 , vol. 141, # 5 p. 569 - 576

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摘要

Abstract A novel synthesis of pyrazole-4-carboxamides is reported. The reaction of N-(3- (dimethylamino)-2-formylacryloyl) formamide, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile, with hydrazine hydrate or monosubstituted hydrazines provides such compounds in good yields. This method has advantages over other methods for construction of such ring systems previously described in the literature. Graphical abstract