Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones

…, M Wu, TK Jones, KB Marschke, A Negro-Vilar…

文献索引：van Oeveren, Arjan; Pio, Barbara A.; Tegley, Christopher M.; Higuchi, Robert I.; Wu, Min; Jones, Todd K.; Marschke, Keith B.; Negro-Vilar, Andres; Zhi, Lin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1523 - 1526

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被引用次数: 28

摘要

A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.