Oxime carbamate—discovery of a series of novel FAAH inhibitors

SY Sit, CM Conway, K Xie, R Bertekap, C Bourin…

文献索引：Sit; Conway, Charles M.; Xie, Kai; Bertekap, Robert; Bourin, Clotilde; Burris, Kevin D. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1272 - 1277

全文：HTML全文

被引用次数: 22

摘要

A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of ...