A Formal Total Synthesis of Epothilone A: Enantioselective Preparation of the C1-C6 and C7-C12 Fragments1

RE Taylor, GM Galvin, KA Hilfiker…

文献索引：Taylor, Richard E.; Galvin, Gabriel M.; Hilfiker, Kerry A.; Chen, Yue Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9580 - 9583

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被引用次数: 30

摘要

Our continued interest in the anticancer agent paclitaxel is driven by the desire to understand the structural features and spatial arrangement necessary for tubulin binding2 and stabilization of microtubule dynamics. 3 The recently reported class of natural products, epothilone, now provides us with compounds structurally distinct from taxol and taxol analogues but with similar biological activity. In addition, epothilones have much greater ...