Hydantoins as antitumor agents

TR Rodgers, MP LaMontagne…

文献索引：Rodgers,T.R. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 591 - 594

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被引用次数: 65

摘要

Method A (2, 4, 6, 8, 10, and 12). Each of these diethyl esters was prepared by the reductive condensation of the appropriately substituted 6-cyanoquinazoline with diethyl 4- aminobenzoyl-L-glutamate or diethyl 4-aminobenzoyl-~-aspartate in the presence of Raney nickel as originally described by Davoll and Johnson." However, in the case of 10 and 12 final purification was achieved by column chromatography on silica gel using benzene- ...