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Chemoselective synthesis of protected polyamines and facile synthesis of polyamine derivatives using O-alkyl-O'-(N-succinimidyl) carbonates

M Adamczyk, JR Fishpaugh…

文献索引:Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Heuser, Kevin J. Organic Preparations and Procedures International, 1998 , vol. 30, # 3 p. 339 - 348

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被引用次数: 18

摘要

Recent interest in polyamines, which can serve as scaffolds for combinatorial libraries, peptidyl polyamines, chelates with gadolinium and other metals, has led to renewed efforts for their Previous syntheses of such compounds generally require cumbersome, stepwise synthesis from protected small amine building blocks. 7-9 Although there are literature examples describing synthesis of selectively protected polyamines, these methods ...