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Process research and development for the kilogram manufacture of the SRC kinase inhibitor AZD0530

JG Ford, SM Pointon, L Powell…

文献索引:Organic Process Research and Development, , vol. 14, # 5 p. 1078 - 1087

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被引用次数: 9

摘要

... Organic Process Research & Development. ... One final note of caution with this process was the detection of ppm quantities of hydrogen cyanide in the off gases ... Conversion of 15 to isatin 16 was also examined by using the reported procedure for isatin.(3) Following the literature ...