Tetrahedron letters

An expeditious synthesis of 6-aminophenanthridines

F Gug, M Blondel, N Desban, S Bouaziz, JM Vierfond…

文献索引：Gug, Fabienne; Blondel, Marc; Desban, Nathalie; Bouaziz, Serge; Vierfond, Jean-Michel; Galons, Herve Tetrahedron Letters, 2005 , vol. 46, # 21 p. 3725 - 3727

全文：HTML全文

被引用次数: 11

摘要

A simple synthesis of biologically active 6-aminophenanthridines was achieved by a Suzuki– Miyaura coupling reaction. Condensation of 2-(4, 4, 5, 5-tetramethyl-1, 3-dioxaborolan-2-yl) aniline with 2-chlorobenzonitriles afforded 6-aminophenanthridines useful as prions inhibitors in a mild one-step procedure. The intermediate 2-amino-2′ cyanobiphenyls could not be isolated.