Tetrahedron

A convenient synthesis of 3, 4-dihydro-1, 4-benzoxazin-2-ones

N Zidar, D Kikelj

文献索引：Zidar, Nace; Kikelj, Danijel Tetrahedron, 2008 , vol. 64, # 24 p. 5756 - 5761

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被引用次数: 6

摘要

3, 4-Dihydro-1, 4-benzoxazin-2-one was prepared for the first time by catalytic hydrogenation of 4-benzyl-3, 4-dihydro-1, 4-benzoxazin-2-one. A simple and efficient synthesis of 4-benzyl-and 4-alkyl-3, 4-dihydro-1, 4-benzoxazin-2-one derivatives from ethyl 2-(2-hydroxyphenylamino) acetate and aldehydes is described. Some considerations regarding the reactivity of 3, 4-dihydro-1, 4-benzoxazin-2-ones are given.