The important advances made in enantioselective catalytic CÀH and CÀC bond-forming reactions generally rely on the careful and time-consuming optimization of the structure of the chiral catalyst to obtain the maximum enantioselectivity and catalytic activity. Very subtle changes to the catalyst structure can often make large (and unpredictable) differences to the performance of the catalyst, especially in terms of the enantioselectivity. Given the great ...
