Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

D Tsvelikhovsky, SL Buchwald

文献索引：Tsvelikhovsky, Dmitry; Buchwald, Stephen L. Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231

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被引用次数: 62

摘要

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and ...