Tricyclics with analgesic and antidepressant activity. 1.[[(Alkylamino) ethyl] thio] dibenz [b, f] oxepins and 10, 11-dihydro derivatives

…, JA Profitt, VB Anderson, TC Spaulding…

文献索引：Ong; Profitt; Anderson; Spaulding; Wilker; Geyer IIIrd; Kruse Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 494 - 501

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被引用次数: 24

摘要

16a-d, R,= R,= CH, l7a, c, d, R,= R,= C, H, 22a, R,= H; R,=(CH,), C, H, a, X= H; b, X= F; c, X= C1; d, X= SCH, screening. Compounds of this type appeared of interest to us because there had only been a few reported examples of tricyclics incorporating a sulfur moiety in the side hai in.^^^ It is interesting to note that two clinically investigated antipsychotic agents, amethothepine (111) and amethoclothepine (IV), 6 bear topographical resemblance to ...