Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl) propyl]-1H-pyrazole-5-carboxamide derivatives

L Nagarapu, J Mateti, HK Gaikwad, R Bantu…

文献索引：Nagarapu, Lingaiah; Mateti, Jhansi; Gaikwad, Hanmant K.; Bantu, Rajashaker; Sheeba Rani; Prameela Subhashini Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4138 - 4140

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被引用次数: 34

摘要

Abstract A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl) propyl]-1H-pyrazole-5- carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.