Efficient chemoenzymatic synthesis of O-linked sialyl oligosaccharides

…, K Allin, L Pereira, A Datta, JC Paulson

文献索引：Blixt, Ola; Allin, Kirk; Pereira, Laura; Datta, Arun; Paulson, James C. Journal of the American Chemical Society, 2002 , vol. 124, # 20 p. 5739 - 5746

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被引用次数: 85

摘要

The tumor associated Tn (GalNAcα (1-1)-Thr/Ser)-and T (Galβ (1-3)-GalNAcα (1-1) Thr/Ser)- antigens and their sialylated derivatives are present on the surface of many cancer cells. Preparative synthesis of these sialylated T-and Tn-structures has been achieved mainly from a chemical synthetic approach due to the lack of the required glycosyltransferases. We demonstrate a flexible and efficient chemoenzymatic approach for using recombinant ...