Synthesis and gastric antisecretory properties of 15-deoxy-16-hydroxyprostaglandin E analogs

PW Collins, EZ Dajani, DR Driskill…

文献索引：Collins,P.W. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1152 - 1159

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被引用次数: 46

摘要

The preparation and gastric antisecretory activity of a series of 15-deoxy-16- hydroxyprostaglandin analogues are described. The compounds were tested intravenously in histamine-stimulated Heidenhain pouch dogs in relation to the reference standards PGEl and PGEl methyl ester (PGEIME). The parent compound of this series,(&)-15-deoxy-16a,/3- hydroxyprostaglandin El methyl ester (3), was found to be equipotent to the reference ...