New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1, 3-thiazol-2-yl] benzamides and furamides

…, V Sudarsanam, S Kachler, D Sabbadin, S Moro…

文献索引：Inamdar, Gajanan S.; Pandya, Amit N.; Thakar, Hardik M.; Sudarsanam, Vasudevan; Kachler, Sonja; Sabbadin, Davide; Moro, Stefano; Klotz, Karl-Norbert; Vasu, Kamala K. European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 924 - 934

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被引用次数: 14

摘要

A series of [5-substituted-4-phenyl-1, 3-thiazol-2-yl] benzamide and furamide analogues were investigated in radioligand binding studies at adenosine receptor subtypes with an aim to obtain potent and selective adenosine receptor ligands. Benzamide and furamide linked to thiazole was found to be crucial for high adenosine receptor affinity. The most potent compound indentified in this study was 5d with low nanomolar affinity for all four ...