Green chemical synthesis of 2-benzenesulfonyl-pyridine and related derivatives

WG Trankle, ME Kopach

文献索引：Trankle, William G.; Kopach, Michael E. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 913 - 917

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被引用次数: 28

摘要

A practical synthesis of 2-benzenesulfonylpyridine, 1, is described which is a key starting material for the manufacture of an investigational new drug candidate at Eli Lilly and Company. An optimized green chemical process was developed which features a novel tandem SNAr/oxidation under mild conditions to produce the target sulfone, 1, in 86% yield and> 99% purity. In addition, this novel, environmentally friendly methodology was found ...