Design and synthesis of 1, 2-dithiolane derivatives and evaluation of their neuroprotective activity

M Koufaki, C Kiziridi, F Nikoloudaki…

文献索引：Koufaki, Maria; Kiziridi, Christina; Nikoloudaki, Faidra; Alexis, Michael N. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4223 - 4227

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被引用次数: 37

摘要

We designed and synthesized new analogues containing 1, 2-dithiolane-3-alkyl and protected or free catechol moieties connected through heteroaromatic rings such as triazole, 1, 2, 4-oxadiazole, 1, 3, 4-oxadiazole, tetrazole or thiazole in order to explore the influence of the bioisosteric replacement of the amide group on the neuroprotective activity of the lipoic acid/dopamine conjugate. Evaluation of the activity of the new compounds, using ...