Tetrahedron: Asymmetry

Lipase catalyzed acylation of primary alcohols with remotely located stereogenic centres: the resolution of (±)-4, 4-dimethyl-3-phenyl-1-pentanol

S Sabbani, E Hedenström, J Andersson

文献索引：Sabbani, Sunil; Hedenstroem, Erik; Andersson, Jimmy Tetrahedron Asymmetry, 2007 , vol. 18, # 14 p. 1712 - 1720

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被引用次数: 17

摘要

Enantioselective acylation of some (±)-3-alkyl-3-phenyl-1-propanols was performed with enzymes as catalysts. Moderate enantiomeric ratios (E), ranging up to E= 11.6, were obtained. In the resolution, some of the lipases selectively acylated the (+)-enantiomer while others acylated the (−)-enantiomer of the γ-substituted primary alcohols 1–4. Thus, it is possible to obtain both enantiomers of the alcohols as remaining substrate with high ...